A comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology
نویسندگان
چکیده
منابع مشابه
Next generation sequencing in clinical diagnostics
Next generation sequencing (NGS) is a moniker used to represent multiple highthroughput or massively parallel nucleic acid sequencing technologies that have emerged since the mid 2000s. These technologies collectively constitute some of the greatest advances made in biomedical sciences in the past three decades (Meldrum et al., 2011). Utilizing NGS approaches, it has become possible for a singl...
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In 1980, Fred Sanger and Walter Gilbert were awarded the Nobel Prize in Chemistry for discovering novel ways for sequencing nucleic acids. In 2003, the human genome sequence was published, an effort that involved more than 3000 scientists from 6 countries. The work took 13 years to complete, at a cost of nearly $3 billion. Only 6 years later, nucleic acid sequencing technologies have advanced t...
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Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
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Recent scientific discoveries that resulted from the application of next-generation DNA sequencing technologies highlight the striking impact of these massively parallel platforms on genetics. These new methods have expanded previously focused readouts from a variety of DNA preparation protocols to a genome-wide scale and have fine-tuned their resolution to single base precision. The sequencing...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2020
ISSN: 2051-5960
DOI: 10.1186/s40478-020-01000-w